As an autonomous and juridical entity, the IRCSS Foundation Istituto Neurologico "Carlo Besta" is a national public body whose mission is to pursue excellence in research- mainly clinical and translational - in the biomedical field,while managing health services by providing high quality care and treatment. The Institute takes a leading role in the development of national strategies for neurology and neuroscience, and is internationally recognized as a center of excellence for the study of the basic mechanism of neurological diseases. The Fondazione participates with 1) the Department of Neurosurgery and 2) the NanoMedicine laboratory. The Department of Neurosurgery is an internationally recognized Italian Tertiary referral center for the treatment of complex CNS neoplasms. It treats over 1000 brain tumours per year and has a solid experience in the management of all kind of brain tumours including high-grade gliomas. Unit 1 is specifically involved in brain tumour clinical activities and research, collaborating in several international multi-center CTs. Unit 1 is endowed with state of the art neurosurgical equipment including 4 fully equipped operating rooms, 3 neuronavigators, 1 Ultrasound neuronavigator, and 2 sterotactic frames.